Bi-wiring: two vs. four

[McGlentosh]

Has anyone compared using internally bi-wired cables (four connectors on one end, two on the other) to running two separate cables? While there's certainly a $$ cost difference, is there a sonic difference?

[Sim reality]

From what I have gleamed from this article there is a difference in bi-wiring to speakers that have are posts for it.

http://www.st-andrews.ac.uk/~www_pa/Scots_Guide/audio/biwire/Page1.html

But if you are running 2 wires to the same posts the only advantage is the reduced resistance which could have been had by running a heavier gauge wire.